反応 #9300

反応方程式

2-Ethyl-4-methoxy-7-(2-methoxy-4,6-dimethylphenyl)-3-nitropyrazolo[1,5-a]pyridine

acetic acid

→

2-ethyl-4-methoxy-7-(2-methoxy-4,6-dimethylphenyl)pyrazolo[1,5-a]pyridin-3-amine

溶媒

ethanol

water

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered with celite
2. 2
   濃縮the obtained filtrate was concentrated under reduced pressure
3. 3
   workup.ADDITIONWater was added
4. 4
   抽出extraction
5. 5
   洗浄the extract was washed with saturated aqueous sodium hydrogencarbonate and brine
6. 6
   乾燥dried over magnesium sulfate
7. 7
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

実験手順

2-Ethyl-4-methoxy-7-(2-methoxy-4,6-dimethylphenyl)-3-nitropyrazolo[1,5-a]pyridine (185 mg) was dissolved in a mixture of ethanol (7 mL) and water (7.5 mL), and then acetic acid (0.3 mL) and zinc powder (185 mg) were added and the reaction mixture was heated at 60° C. for 20 minutes. The reaction mixture was filtered with celite, and the obtained filtrate was concentrated under reduced pressure. Water was added, extraction was performed with ethyl acetate, the extract was washed with saturated aqueous sodium hydrogencarbonate and brine and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 2-ethyl-4-methoxy-7-(2-methoxy-4,6-dimethylphenyl)pyrazolo[1,5-a]pyridin-3-amine as a crude product.

出典