反応 #92972

反応方程式

1,4-dichloro-2-butanol

m-trifluoromethylphenol

potassium hydroxide

→

4-Chloro-1-(3-trifluoromethylphenoxy)-2-butanol

溶媒

water

water

isopropanol

反応条件

後処理

1. 1
   その他The resulting reaction mixture
2. 2
   抽出extracted with 400 ml
3. 3
   抽出The ether extract
4. 4
   洗浄was washed with 0.5N sodium hydroxide
5. 5
   乾燥with water, dried over sodium sulfate
6. 6
   workup.DISTILLATIONdistilled under reduced pressure
7. 7
   workup.DISTILLATIONThe distillate which was collected at 120°-124° C./0.01 mm
8. 8
   その他solidified at room temperature

実験手順

To a mixture of 0.5 mole (75 g.) of m-trifluoromethylphenol, 1 mole (56 g.) of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 0.6 mole (84 g.) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr., mixed with 2 liters of water, and extracted with 400 ml. of isopropyl ether. The ether extract was washed with 0.5N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm. solidified at room temperature and melted at 50°-52° C.

出典