反応 #92971

反応方程式

1,4-dichloro-2-butanol

4-phenylphenol

sodium hydroxide

→

4-Chloro-(4-biphenylyloxy)-2-butanol

溶媒

water

反応条件

後処理

1. 1
   温度The resulting mixture was heated at 68° C. in a steam bath for 6 hr
2. 2
   温度, cooled
3. 3
   抽出extracted with 300 ml
4. 4
   抽出The chloroform extract
5. 5
   洗浄was washed with water to neutrality
6. 6
   乾燥dried over sodium sulfate
7. 7
   濃縮concentrated to dryness
8. 8
   その他The solid residue was recrystallized with isopropanol
9. 9
   その他yielded 180 g

実験手順

To a solution of 1 mole (158 g.) of 4-phenylphenol 100 g. of sodium hydroxide and 500 ml. of water was added 1 mole (143.02 g.) of 1,4-dichloro-2-butanol with stirring at 40° C. The resulting mixture was heated at 68° C. in a steam bath for 6 hr., cooled and extracted with 300 ml. of chloroform. The chloroform extract was washed with water to neutrality, dried over sodium sulfate and concentrated to dryness. The solid residue was recrystallized with isopropanol and yielded 180 g. of a white crystalline solid which melted at 123°-124° C.

出典