反応 #92929

反応方程式

1-bromo-2-(4-methylphenyl)-2-oxoethane

1-methylimidazole

→

1-methyl-3-[2-(4-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide

収率 32.4%

溶媒

diethyl ether

反応条件

後処理

1. 1
   ろ過the precipitated solid was collected by filtration
2. 2
   その他The resulting hygroscopic solid was recrystallized from methanol/ethyl acetate

実験手順

To a solution of 10.6 g (0.05 mol) of 1-bromo-2-(4-methylphenyl)-2-oxoethane in 150 ml of diethyl ether was added 4.18 g (0.051 mol) of 1-methylimidazole (Aldrich Chemical Company, Milwaukee, Wis.). The reaction mixture was stirred for approximately 3 hours at room temperature and the precipitated solid was collected by filtration. The resulting hygroscopic solid was recrystallized from methanol/ethyl acetate to afford 4.82 g of 1-methyl-3-[2-(4-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide as a solid. A second crop was obtained from the filtrate to provide an additional 5.8 g of product. (72% yield) mp=148°-151° C.

出典