反応 #929

反応方程式

2,6-dinitrobenzonitrile

thiophenol

K2CO3

Pyridine

→

2-nitro-6-(phenylthio)benzonitrile

収率 89.0%

溶媒

H2O

DMF

反応条件

後処理

1. 1
   ろ過The yellow precipitate was collected by filtration
2. 2
   洗浄washed with 1N NaOH, water
3. 3
   その他dried

実験手順

An ice water bath-cooled mixture of 2.0 g (0.01 mol) of 2,6-dinitrobenzonitrile (Lancaster Synthesis, Inc., Windham, N.H. 03087), 1.06 ml (0.01 mol) of thiophenol, and 1.44 g (0.01 mol) of anhydrous K2CO3 in 50 mL of DMF was stirred for 0.5 h. Pyridine was added to the reaction mixture until it became basic, and was followed by the addition of approximately 100 mL of H2O. The yellow precipitate was collected by filtration, washed with 1N NaOH, water and dried to give 1.94 g (89%) of 2-nitro-6-(phenylthio)benzonitrile as a yellow solid: mp 106°-107° C.

出典