反応 #92863

反応方程式

2-(4-hydroxyphenoxy)quinoxaline

sodium hydride

hydrogen

dimethyl 2-bromo-2-methylpropanedioate

→

title compound

Dimethyl 2-methyl-2-[4-(2-quinoxalinyloxy)phenoxy]propanedioate

反応条件

後処理

1. 1
   workup.ADDITIONWhen the addition
2. 2
   抽出extract with ether

実験手順

In a nitrogen atmosphere, add a solution of 4.8 g (0.02 mole) 2-(4-hydroxyphenoxy)quinoxaline in 30 cc dimethylfornmamide to 0.8 (0.02 mole) 57% sodium hydride. When the evolution of hydrogen ceases, add 4.8 g (0.021 mole) dimethyl 2-bromo-2-methylpropanedioate dropwise. When the addition is complete, heat at approximately 70° C. until the reaction is complete. Pour the mixture into ice-water and extract with ether. Concentration of the dry ethereal extracts yield the title compound.

出典