反応 #928305

反応方程式

isopropyl ether

( XIX )

triethylenglycol bis-acetylsalicylate

chloride

1.10-decandiol

acetylsalicylic acid

→

1.10-decandiol bis-acetylsalicylate

反応条件

後処理

1. 1
   その他The compound (IV) was prepared
2. 2
   その他The product was purified by chromatography
3. 3
   workup.ADDITIONmix
4. 4
   その他The intermediate fractions were collected
5. 5
   その他the solvent was evaporated under reduced pressure
6. 6
   その他a solid residue was obtained which

実験手順

The compound (IV) was prepared according to the procedure described in Example 1 for the synthesis of (XIX), starting from 5 g of the chloride of acetylsalicylic acid, 3.5 ml of TEA and 2.17 g of 1.10-decandiol. The product was purified by chromatography utilizing an eluent mix constituted by ethylether/hexane 7:3 (v/v). The intermediate fractions were collected, the solvent was evaporated under reduced pressure and a solid residue was obtained which, trirurated with isopropyl ether, produced 1.37 g of 1.10-decandiol bis-acetylsalicylate (IV) with m.p.=75° C.

出典