反応 #92819

反応方程式

N-(4-bromo-2,6-diisopropylphenyl)-3-methoxybenzimidamide

2-chloroacetaldehyde

sodium bicarbonate

2-Propanol

→

desired product

収率 79.0%

1-(4-bromo-2,6-diisopropylphenyl)-2-(3-methoxyphenyl)-1H-imidazole

収率 79.0%

溶媒

water

反応条件

後処理

1. 1
   温度to reflux for 16 hours
2. 2
   抽出extracted with ethyl acetate

実験手順

A 500 ml round bottom flask was charged with N-(4-bromo-2,6-diisopropylphenyl)-3-methoxybenzimidamide (19.73 g, 50.7 mmol), 2-chloroacetaldehyde (12.83 ml, 101 mmol), sodium bicarbonate (12.77 g, 152 mmole) and 2-Propanol (300 ml). The reaction was allowed to reflux for 16 hours. The reaction mixture was diluted with deionized water and extracted with ethyl acetate, the organic portion was combined and subjected to a column chromatography (SiO2 gel; 20% THF in heptane) to yield the desired product (16.47 g, 79%).

出典