反応 #927243
ord-26c0b651f1384c988b24009e56c91f96
反応方程式
1,1,2-tribromo-2-hexyl-cyclopropane
methyl lithium
water
→
1-hexyl-cyclopropene
収率 87.0%
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度While cooling in an ice water bath
- 2その他The resulting mixture was transferred to a separatory funnel
- 3その他the phases were separated
- 4乾燥The organic layer was dried over MgSO4
- 5ろ過filtered
- 6その他The solvent was removed from the filtrate in vacuo with a bath temperature under 20° C.
実験手順
A solution of 1.01 g (0.00278 mol) of 1,1,2-tribromo-2-hexyl-cyclopropane in 4 ml of diethyl ether was placed under a nitrogen atmosphere via use of a Firestone valve. While cooling in an ice water bath, 6.3 ml (0.00835 mol) of 1.4M methyl lithium in diethyl ether was added slowly by syringe. After 15 minutes, 2 ml of water was added via syringe. The resulting mixture was transferred to a separatory funnel and the phases were separated. The organic layer was dried over MgSO4 and filtered. The solvent was removed from the filtrate in vacuo with a bath temperature under 20° C. to yield 0.300 g (87% of theoretical) of 1-hexyl-cyclopropene pure as an oil.