反応 #927238

反応方程式

Propargylamine

methyl trifluoroacetate

→

N-propargyltrifluoroacetamide

収率 86.0%

反応条件

後処理

1. 1
   その他to react at 0° C. for two hours

実験手順

Propargylamine (Aldrich, 25 g, 0.45 mol) was added dropwise to methyl trifluoroacetate (Tokyo Chemical Industry Co., Ltd., 69.2 g, 0.54 mol) cooled to 0° C. They were allowed to react at 0° C. for two hours to afford 43.8 g (86.0%) of N-propargyltrifluoroacetamide after purification by vacuum distillation (23 mmHg, boiling point; 77° C.).

出典