反応 #927236

反応方程式

7-octynyl-p-toluenesulfonate

sodium iodide

→

8-iodo-1-octyne

収率 94.2%

溶媒

acetone

反応条件

後処理

1. 1
   その他to react for four hours
2. 2
   温度under reflux
3. 3
   温度After cooling
4. 4
   その他the precipitates were removed by filtration
5. 5
   濃縮the filtrate was concentrated
6. 6
   その他The resulting residue was purified by silica gel column chromatography (eluent; hexane)

実験手順

A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).

出典