反応 #927230

反応方程式

t-Butyl ethyl malonate

1,3-dibromo-5,5-dimethylhydantoin

→

light yellow oil

収率 176.5%

t-butyl ethyl bromomalonate

収率 176.5%

溶媒

toluene

反応条件

後処理

1. 1
   温度The reaction was cooled
2. 2
   濃縮concentrated
3. 3
   洗浄The organic layer was washed, with sat. NaHCO3 (2×), brine (3×)
4. 4
   乾燥dried (MgSO4)
5. 5
   ろ過filtered
6. 6
   濃縮concentrated
7. 7
   その他Purification
8. 8
   ろ過by filtration on silica (70:30; hept:EtOAc)

実験手順

t-Butyl ethyl malonate (25.00 g, 0.13 mol) was dissolved in toluene and warmed to 80° C. To the resulting solution was added 1,3-dibromo-5,5-dimethylhydantoin (25.00 g, 0.07 mol). The reaction was stirred at elevated (80° C.) temperature 18 h. The reaction was cooled concentrated and taken up in Et2O. The organic layer was washed, with sat. NaHCO3 (2×), brine (3×), dried (MgSO4), filtered and concentrated. Purification by filtration on silica (70:30; hept:EtOAc) yielded 33.0 g (93%) of a light yellow oil. NMR and MS indicated a mixture of three compounds SM (20%), monobrominated (55%) and dibromonated diesters (25%). The material was used without further purification.

出典