反応 #92712

反応方程式

tert-butyl[(1R,2R)-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate

N-bromosuccinimide

2,2′-azodiisobutyronitrile

→

tert-butyl[(1R,2S)-3-bromo-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate

収率 29.0%

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   workup.ADDITIONwas added portionwise
2. 2
   ろ過The insoluble material was filtered
3. 3
   workup.ADDITIONan aqueous sodium thiosulfate solution and chloroform were added
4. 4
   その他a layer separation operation
5. 5
   乾燥After drying over anhydrous sodium sulfate
6. 6
   その他the solvent was evaporated under reduced pressure
7. 7
   その他The obtained residue was purified by silica gel column chromatography

実験手順

A solution of 2.75 g of tert-butyl[(1R,2R)-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate in 55 ml of carbon tetrachloride was heated at an outer temperature of 100° C., and a mixture of 1.53 g of N-bromosuccinimide and 95 mg of 2,2′-azodiisobutyronitrile was added portionwise thereto over 30 minutes at an interval of 5 minutes, followed by stirring at an outer temperature of 100° C. for 1 hour. The insoluble material was filtered, and an aqueous sodium thiosulfate solution and chloroform were added thereto to carry out a layer separation operation. After drying over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 984 mg of tert-butyl[(1R,2S)-3-bromo-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate.

出典