反応 #92681

反応方程式

chloroform

water

methyl 3-cyclopropyl-3-oxopropanoate

sulfuryl chloride

→

methyl 2-chloro-3-cyclopropyl-3-oxopropanoate

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度cooling
2. 2
   温度cooling
3. 3
   その他a layer separation operation
4. 4
   洗浄The organic layer was washed with saturated brine
5. 5
   乾燥dried over anhydrous sodium sulfate
6. 6
   その他the solvent was evaporated under reduced pressure

実験手順

To a solution of 2 g of methyl 3-cyclopropyl-3-oxopropanoate in 20 ml of dichloromethane was added dropwise 1.24 ml of sulfuryl chloride under ice-cooling, followed by stirring at room temperature for 5 hours. To the reaction mixture was added water under ice-cooling, and chloroform was further added thereto to carry out a layer separation operation. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 2.48 g of methyl 2-chloro-3-cyclopropyl-3-oxopropanoate.

出典