反応 #926

反応方程式

2-Aminonicotinaldehyde

2,6-difluoroacetophenone

KOH

→

desired product

収率 79.0%

2-(2',6'-Difluorophenyl)-1,8-naphthyridine

収率 79.0%

溶媒

MeOH

反応条件

後処理

1. 1
   その他after the exothermic reaction
2. 2
   workup.ADDITIONit is poured onto water
3. 3
   ろ過the residue which is deposited is filtered off with suction

実験手順

2-Aminonicotinaldehyde (2.44 g, 20 mmol) and 2,6-difluoroacetophenone (3.28 g, 21 mmol) are dissolved in 20 ml of MeOH. The mixture is treated dropwise with 3 ml of 40% KOH and, after the exothermic reaction has subsided, it is poured onto water and the residue which is deposited is filtered off with suction. 3.8 g (79% yield) of the desired product are obtained. M.p. 100°-103° C.

出典