反応 #9250

反応方程式

N-[7-(4-bromoanilino)-4,5-dihydro[1,3]thiazolo[4′,5′: 3,4]benzo[d][1,3]thiazol-2-yl]-N′-ethylurea

DDQ

→

N-[7-(4-Bromoanilino)[1,3]thiazolo[4′,5′: 3,4]benzo[d][1,3]thiazol-2-yl]-N′-ethylurea

溶媒

toluene

反応条件

後処理

1. 1
   その他purified by preparative HPLC
2. 2
   その他7 mg (26%, 2 steps) pure product was isolated
3. 3
   その他RP-HPLC 18.09 min.

実験手順

To a suspension of N-[7-(4-bromoanilino)-4,5-dihydro[1,3]thiazolo[4′,5′: 3,4]benzo[d][1,3]thiazol-2-yl]-N′-ethylurea (27 mg, 0.060 mmol) in toluene (2.0 mL) was added DDQ (28 mg, 0.125 mmol). The reaction mixture was stirred at about 20° C. for about 2 hrs. The reaction mixture was pumped down in vacuo and purified by preparative HPLC. 7 mg (26%, 2 steps) pure product was isolated. LC/MS 448 and 450 (MH+); RP-HPLC 18.09 min.

出典