反応 #9246

反応方程式

1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

triethylamine

2-fluorophenyl isocyanate

→

desired compound

収率 26.0%

1-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea

収率 26.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他Similar to the synthesis of Example 249
2. 2
   その他was reacted

実験手順

Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2-fluorophenyl isocyanate in DMF was reacted to give the desired compound 0.022 g (26%). LC/MS 430.01 (M+1); LC retention time 2.89 min.

出典