反応 #9243

反応方程式

1-(6-(3-aminophenyl)-2-benzothiazolyl)-3-ethylurea

1-(6-bromo-2-benzothiazolyl)-3-ethylurea

sodium carbonate

DMF water

→

desired compound

収率 30.0%

1-(6-(4-Pyrazolyl)-2-benzothiazolyl)-3-ethylurea

収率 30.0%

反応条件

後処理

1. 1
   その他was reacted

実験手順

Similar to the synthesis of 1-(6-(3-aminophenyl)-2-benzothiazolyl)-3-ethylurea, a mixture of 4-pyrazolylboronic pinacolate, 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, sodium carbonate, and Pd(PPh3)4 in DMF/water mixed solvent was reacted to give the desired compound 0.543 g (30%). LC/MS 288.2 (M+1); LC retention time 2.61 min.

出典