反応 #9242

反応方程式

1-(6-(3-aminophenyl)-2-benzothiazolyl)-3-ethylurea

triethylamine

phenyl isocyanate

→

desired compound

収率 44.0%

1-(6-(3-Phenylaminocarbonylaminophenyl)-2-benzothiazolyl)-3-ethylurea

収率 44.0%

溶媒

toluene

反応条件

後処理

1. 1
   その他The white precipitation
2. 2
   ろ過was filtered off
3. 3
   洗浄washed with Et2O and MeOH
4. 4
   その他dried under vacuum

実験手順

A suspension of 1-(6-(3-aminophenyl)-2-benzothiazolyl)-3-ethylurea (0.062 g, 0.20 mmol), triethylamine (0.083 mL, 0.60 mmol, 3.0 eq), and phenyl isocyanate (0.055 mL, 0.50 mmol, 2.5 eq) in 2 mL toluene was stirred at room temperature for about 1 hour. The white precipitation was filtered off, washed with Et2O and MeOH, and dried under vacuum to give the desired compound 0.038 g (44%). LC/MS 431.8 (M+1); LC retention time 3.49 min.

出典