反応 #9236

反応方程式

phenyl isocyanate

1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

triethylamine

→

desired compound

収率 22.0%

1(6-(3-Phenylaminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea

収率 22.0%

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGIt was stirred for about 2.5 hours
2. 2
   その他quenched with MeOH
3. 3
   ろ過filtered
4. 4
   濃縮concentrated
5. 5
   その他purified by HPLC

実験手順

A solution of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea (0.033 g, 0.10 mmol) in 1 mL anhydrous DMF was treated with triethylamine (0.028 mL, 0.20 mmol, 2.0 eq) at room temperature. It was stirred for about 5 min, followed by the addition of phenyl isocyanate (0.013 mL, 0.12 mmol, 1.2 eq). It was stirred for about 2.5 hours, quenched with MeOH, filtered, concentrated, and purified by HPLC to give the desired compound 0.009 g (22%). LC/MS 412.2 (M+1); LC retention time 2.80 min.

出典