反応 #9228

反応方程式

1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea

→

desired compound

収率 76.0%

1-(6-(2-Phenylethyl)-2-benzothiazolyl)-3-ethylurea

収率 76.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他was purged with nitrogen gas
2. 2
   その他by bubbling of hydrogen gas
3. 3
   ろ過filtered
4. 4
   濃縮concentrated
5. 5
   その他dried under vacuum

実験手順

A suspension of 1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea (0.048 g, 0.15 mmol) and 10% palladium on carbon (0.016 g, 10% weight purity, 0.015 mmol, 0.10 eq) in 2 mL ethanol was purged with nitrogen gas, followed by bubbling of hydrogen gas. It was stirred under hydrogen atmosphere for about 16 hours. The mixture was taken up in 8 mL MeOH, filtered, concentrated, and dried under vacuum to give 0.037 g (76%) of the desired compound. LC/MS 326.3 (M+1); LC retention time 2.84 min.

出典