反応 #922

反応方程式

3-[[(1,1-dimethylethyl)amino]sulfonyl]-N,N,1-trimethyl-1H-pyrrole-2-carboxamide

TFA

→

title compound

収率 92.9%

3 -(Aminosulfonyl)-N,N,1-trimethyl-1H-pyrrole-2-carboxamide

収率 92.9%

溶媒

methylene chloride

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONThree portions of diethyl ether were added to the residue
3. 3
   その他removed by evaporation
4. 4
   その他to remove residual TFA

実験手順

To a solution of 5.63 g of 3-[[(1,1-dimethylethyl)amino]sulfonyl]-N,N,1-trimethyl-1H-pyrrole-2-carboxamide in 75 mL of methylene chloride was added 75 mL of TFA. The reaction mixture was allowed to stir at room temperature overnight ca. 16 hours. The reaction mixture was concentrated in vacuo. Three portions of diethyl ether were added to the residue and removed by evaporation to remove residual TFA, affording 4.21 g of the title compound as a gray solid, m.p. 185°-190.5° C.

出典