反応 #92199

反応方程式

1-(3-chlorophenyl)-3-(4-chlorophenyl)prop-2-en-1-one

NH4Cl

→

1-(3-chlorophenyl)-3-(4-chlorophenyl)propan-1-one

収率 83.0%

溶媒

water

MeOH

反応条件

後処理

1. 1
   温度The reaction was refluxed for 4 h
2. 2
   ろ過then filtered
3. 3
   濃縮The filtrate was concentrated to a residue which
4. 4
   その他was purified by chromatography PE/EA (5:1)

実験手順

1-(3-chlorophenyl)-3-(4-chlorophenyl)prop-2-en-1-one (1.38 g, 5 mmol), Zn dust (1.95 g, 30 mmol), NH4Cl (2.67 g, 50 mmol) were combined in MeOH (10 mL) and water (5 mL). The reaction was refluxed for 4 h, cooled to RT then filtered. The filtrate was concentrated to a residue which was purified by chromatography PE/EA (5:1) to give 1-(3-chlorophenyl)-3-(4-chlorophenyl)propan-1-one (1.15 g, 83% yield) as a brown solid. MH+ 279 and TR=2.025 min.

出典