反応 #92113

反応方程式

N-(3-chloropropyl)-2,2,2-trifluoroacetamide

BH3/THF

→

(3-chloropropyl)(2,2,2-trifluoroethyl)amine

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他Into a 250-mL round-bottom flask, was placed
2. 2
   濃縮The resulting mixture was concentrated under vacuum
3. 3
   workup.ADDITIONThe resulting solution was diluted with 200 mL of H2O
4. 4
   抽出The resulting solution was extracted with 4×100 mL of ethyl acetate
5. 5
   洗浄The resulting mixture was washed with 2×100 mL of brine
6. 6
   乾燥The mixture was dried over anhydrous sodium sulfate
7. 7
   その他This resulted in 5 g (90%) of (3-chloropropyl)(2,2,2-trifluoroethyl)amine as a light yellow liquid

実験手順

Into a 250-mL round-bottom flask, was placed N-(3-chloropropyl)-2,2,2-trifluoroacetamide (6 g, 31.65 mmol, 1.00 equiv), tetrahydrofuran (30 mL), BH3/THF (80 mL). The resulting solution was stirred for 3 h at 80° C. in an oil bath. The resulting mixture was concentrated under vacuum. The resulting solution was diluted with 200 mL of H2O. The resulting solution was extracted with 4×100 mL of ethyl acetate and the organic layers combined. The resulting mixture was washed with 2×100 mL of brine. The mixture was dried over anhydrous sodium sulfate. This resulted in 5 g (90%) of (3-chloropropyl)(2,2,2-trifluoroethyl)amine as a light yellow liquid.

出典