反応 #92010

反応方程式

cyclopentanecarboxylic acid methyl ester

diisopropylamine

1,4-dibromobutane

n-butyllithium

→

title compound

1-(4-bromobutyl)cyclopentanecarboxylic acid methyl ester

反応条件

後処理

1. 1
   workup.DISTILLATIONafter distillation

実験手順

The title compound was prepared using a similar procedure as described in Example 1, Step 1, starting from diisopropylamine (21 mL, 150 mmol), n-butyllithium (58 mL, 145 mmol), cyclopentanecarboxylic acid methyl ester (13.1 g, 100 mmol), and 1,4-dibromobutane (21.59 g, 100 mmol), and after distillation, resulted in a colorless oil (12.8 g, 48%). ES(+)-HRMS m/e calcd. for C11H19BrO2 (M+H)+ 262.0568, obsd. 262.0565.

出典