反応 #9186

反応方程式

ethyl-2-amino-4-trifluoromethyl-thiazole-5-carboxylate

di-t-butyldicarbonate

→

title compound

収率 92.0%

Ethyl-2-tert-butoxycarbonyloxyamino-4-trifluoromethyl-thiazole-5-carboxylate

収率 92.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他The solvent was evaporated in vacuo
2. 2
   その他The residue was chromatographed on a silica gel column
3. 3
   洗浄Elution with 5% EtOAc in hexanes

実験手順

A suspension of ethyl-2-amino-4-trifluoromethyl-thiazole-5-carboxylate (5.05 g, 21.02 mmol), di-t-butyldicarbonate (4.82 g, 22.07 mmol) and 4-dimethylaminopyridine (260 mg, 2.1 mmol) in dichloromethane (209 mL) was stirred under nitrogen for 1.5 h. The solvent was evaporated in vacuo. The residue was chromatographed on a silica gel column. Elution with 5% EtOAc in hexanes, followed by 15% EtOAc in hexanes afforded the title compound (6.57 g, 92%) as a white solid.

出典