反応 #91662

反応方程式

sodium carbonate

3-Bromophenol

pyridin-3-ylboronic acid

→

3-(pyridin-3-yl)phenol

収率 78.8%

溶媒

dimethoxyethane water

反応条件

後処理

1. 1
   その他After the completion of the reaction
2. 2
   ろ過the reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   抽出extracted with ethyl acetate
5. 5
   乾燥The obtained organic layer was dried over magnesium sulfate
6. 6
   その他purified by column chromatography (hexane:ethyl acetate=9:1)

実験手順

3-Bromophenol (500 mg, 2.86 mmol) and pyridin-3-ylboronic acid (422 mg, 3.76 mmol) were dissolved in dimethoxyethane/water=5 mL/2.5 mL. Pd(dppf)Cl2 (118 mg, 0.14 mmol) and sodium carbonate (919 mg, 8.67 mmol) were added thereto, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 3-(pyridin-3-yl)phenol (386 mg, 78%).

出典