反応 #91549

反応方程式

2-bromo-3-pyridinol

potassium carbonate

2-(chloromethyl)-4-methylpyridine hydrochloride

→

title compound

2-bromo-3-{[(4-methyl-2-pyridinyl)methyl]oxy}pyridine

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGThis was stirred at room temperature overnight
2. 2
   その他the solid formed
3. 3
   ろ過was collected by filtration
4. 4
   洗浄washed with hexane
5. 5
   その他dried

実験手順

A mixture of 2-bromo-3-pyridinol (commercially available, e.g. from Aldrich) (2.9 g) and potassium carbonate (6.94 g) in DMF (25 ml) was stirred for 20 min before adding 2-(chloromethyl)-4-methylpyridine hydrochloride (for preparation see WO 2008/141011) (3 g). This was stirred at room temperature overnight. The reaction mixture was poured into ice/water and the solid formed was collected by filtration, washed with hexane and dried to give the title compound, 2.87 g (61%).

出典