反応 #91500

反応方程式

compound 1h

(2-Phenyl-thiazol-4-yl)-(3,4,5-trimethoxy-phenyl)-methanone

2-(1H-indol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

cysteine

→

(2-(1H-indol-2-yl)thiazol-4-yl)(1H-indol-5-yl)methanone

反応条件

実験手順

(2-(1H-indol-2-yl)thiazol-4-yl)(1H-indol-5-yl)methanone (21) was prepared using the similar method as used of compound 1h from 2-(1H-indol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid and cysteine. 1H NMR (500 MHz, CDCl3) δ 9.60 (s, 1H), 9.26 (s, 1H), 8.31 (s, 1H), 8.03 (s, 1H), 7.83 (dd, 1H), 7.69 (d, 1H), 7.53-7.49 (m, 2H), 7.41 (t, 1H), 7.33 (t, 1H), 7.21-7.18 (m, 2H), 7.13 (s, 1H). MS (ESI) m/z 366.1 (M+Na)+, 341.9 (M−H)−.

出典