反応 #91416

反応方程式

N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

cyclobutanamine

→

titled compound

5,6-dimethyl-N4-(pentan-3-yl)-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

反応条件

後処理

1. 1
   その他The titled compound was synthesized
2. 2
   その他The crude material was purified by column chromatography
3. 3
   洗浄eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. 4
   洗浄the final product was washed with diethyl ether

実験手順

The titled compound was synthesized according to the procedure described for preparation of N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 29) using cyclobutanamine instead of cyclopentanamine. The crude material was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a white solid. 1H NMR (300 MHz, CDCl3) δ ppm 0.81 (t, J=7.3 Hz, 3H), 1.36-1.43 (m, 2H), 1.50-1.57 (m, 2H), 1.90 (s, 3H), 2.26 (s, 3H), 3.94-4.00 (m, 1H), 4.17 (bs, 1H), 4.72 (d, J=5.9 Hz, 2H), 5.72 (bs, 1H), 7.13 (t, J=7.5 Hz, 1H), 7.36 (d, J=7.3 Hz, 1H), 7.60 (t, J=7.5 Hz, 1H), 8.54 (d, J=4.8 Hz, 1H); MS (ESI) m/z 300.1 (M+1)+.

出典