反応 #91335
ord-f5b5ba91d40b483ba752763662e7a85d
反応方程式
4-methylbenzylamine
3-fluoroisonicotinic acid
→
title compound
収率 51.0%
3-[(4-methylbenzyl)amino]pyridine-4-carboxylic acid
収率 51.0%
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
The title compound was prepared in 51% yield from 4-methylbenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.41 (br s, 1H), 8.13 (s, 1H), 7.81 (d, 1H, J=5.0 Hz), 7.56 (d, 1H, J=5.0 Hz), 7.25 (d, 2H, J=7.9 Hz), 7.15 (d, 2H, J=7.8 Hz), 4.50 (s, 2H), 2.28 (s, 3H). [M+H] calc'd for C14H14N2O2, 243. found 243.