反応 #91328
ord-3cf326b2c4e14e13857a179087d14083
反応方程式
2,4-dimethoxybenzylamine
3-fluoroisonicotinic acid
→
title compound
収率 61.0%
3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxylic acid
収率 61.0%
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
The title compound was prepared in 61% yield from 2,4-dimethoxybenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.41 (br s, 1H), 8.20 (s, 1H), 7.80 (d, 1H, J=5.0 Hz), 7.54 (d, 1H, J=5.0 Hz), 7.18 (d, 1H, J=8.3 Hz), 6.59 (d, 1H, J=2.4 Hz), 6.48 (dd, 1H, J=8.3, 2.4 Hz), 4.40 (s, 2H), 382 (s, 3H), 3.74 (s, 3H). [M+H] calc'd for C15H16N2O4, 259. found 259.