反応 #91293

反応方程式

3-Chloromethyl-2-cyclopropylmethylsulfanyl-pyridine

3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester

→

title compound

収率 74.0%

3-[3-chloro-4-(2-cyclopropylmethylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid

収率 74.0%

反応条件

後処理

1. 1
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

3-Chloromethyl-2-cyclopropylmethylsulfanyl-pyridine (35 mg, 0.16 mmol) obtained in Step C of Preparation Example 18 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (42 mg, 0.18 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (38 mg, 74%).

出典