反応 #91291

反応方程式

2-Chloromethyl-6-cyclobutylsulfanyl-pyridine

2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid methyl ester

→

title compound

収率 88.0%

2-[4-(6-cyclobutylsulfanyl-pyridin-2-ylmethoxy)-3,5-difluoro-phenyl]-cyclopropane carboxylic acid

収率 88.0%

反応条件

後処理

1. 1
   その他obtained in Step C of Preparation Example 60
2. 2
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

2-Chloromethyl-6-cyclobutylsulfanyl-pyridine (0.018 g, 0.08 mmol) obtained in Step C of Preparation Example 37 and 2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid methyl ester (more polar) (0.020 g, 0.08 mmol) obtained in Step C of Preparation Example 60 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.030 g, 88%).

出典