反応 #91268

反応方程式

3-Chloromethyl-2-propylsulfanyl-pyridine

2-(3-fluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid methyl ester

→

title compound

収率 48.0%

2-[3-fluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

収率 48.0%

反応条件

後処理

1. 1
   その他obtained in Step C of Preparation Example 64
2. 2
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

3-Chloromethyl-2-propylsulfanyl-pyridine (0.016 g, 0.08 mmol) obtained in Step C of Preparation Example 14 and 2-(3-fluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid methyl ester (less polar) (0.017 g, 0.08 mmol) obtained in Step C of Preparation Example 64 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.014 g, 48%).

出典