反応 #91250

反応方程式

3-Chloromethyl-2-isopropylsulfanyl-pyridine

2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

収率 80.0%

2-[3-chloro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

収率 80.0%

反応条件

後処理

1. 1
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

3-Chloromethyl-2-isopropylsulfanyl-pyridine (33 mg, 0.16 mmol) obtained in Step C of Preparation Example 1 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (43 mg, 0.17 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (42 mg, 80%).

出典