反応 #91241

反応方程式

2-Chloromethyl-6-cyclobutylsulfanyl-pyridine

2-(3-fluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

収率 92.4%

2-[4-(6-cyclobutylsulfanyl-pyridin-2-ylmethoxy)-3-fluoro-phenyl]-cyclopropane carboxylic acid

収率 92.4%

反応条件

後処理

1. 1
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

2-Chloromethyl-6-cyclobutylsulfanyl-pyridine (0.044 g, 0.20 mmol) obtained in Step C of Preparation Example 37 and 2-(3-fluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (0.046 g, 0.20 mmol) obtained in Step C of Preparation Example 44 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.069 g, 90%).

出典