反応 #91240

反応方程式

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine

2-(3-fluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

収率 92.6%

2-[4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-3-fluoro-phenyl]-cyclopropane carboxylic acid

収率 92.6%

反応条件

後処理

1. 1
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (0.040 g, 0.17 mmol) obtained in Step C of Preparation Example 27 and 2-(3-fluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (0.040 g, 0.17 mmol) obtained in Step C of Preparation Example 44 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.061 g, 89%).

出典