反応 #91239

反応方程式

3-Chloromethyl-2-isopropylsulfanyl-pyridine

2-[3-fluoro-4-hydroxy-phenyl]-cyclopropane carboxylic acid ethyl ester

→

title compound

収率 84.0%

2-[3-fluoro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

収率 84.0%

反応条件

後処理

1. 1
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.040 g, 0.20 mmol) obtained in Step C of Preparation Example 1 and 2-[3-fluoro-4-hydroxy-phenyl]-cyclopropane carboxylic acid ethyl ester (0.044 g, 0.20 mmol) obtained in Step C of Preparation Example 44 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.060 g, 84%).

出典