反応 #91237

反応方程式

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine

((S)-6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

→

title compound

収率 70.0%

[(S)-6-(2-cyclopentylsulfanyl-pyridin-3-ylmethoxy)-2,3-dihydro-benzofuran-3-yl]-acetic acid

収率 70.0%

反応条件

後処理

1. 1
   その他obtained in Preparation Example 56
2. 2
   その他to react sequentially in the same manner as in Steps A and B of Example 1

実験手順

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (11 mg, 0.05 mmol) obtained in Step C of Preparation Example 8 and ((S)-6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (10 mg, 0.05 mmol) obtained in Preparation Example 56 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (13 mg, 70%).

出典