反応 #91195

反応方程式

2-Fluoro-4-methoxy-benzaldehyde

carbethoxy methylene triphenylphosphorane

→

title compound

収率 83.0%

(E)-3-(2-fluoro-4-methoxy-phenyl)-acrylic acid ethyl ester

収率 83.0%

溶媒

THF

反応条件

後処理

1. 1
   その他After the termination of the reaction
2. 2
   温度the reactant was cooled
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他purified by column chromatography (eluent, EtOAc/Hex=1/10)

実験手順

2-Fluoro-4-methoxy-benzaldehyde (1.24 g, 3.56 mmol) and carbethoxy methylene triphenylphosphorane (2.0 g, 5.78 mmol) were dissolved in THF (10 mL), and the mixture was stirred at 65˜75° C. for 1 hour. After the termination of the reaction, the reactant was cooled, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/10) to obtain the title compound (0.6 g, 83%).

出典