反応 #91172

反応方程式

Sulfuric acid

ethyl 4-chloroacetoacetate

2,4-difluororesorcinol

→

title compound

収率 24.0%

4-chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone

収率 24.0%

溶媒

反応条件

後処理

1. 1
   ろ過The precipitate was filtered
2. 2
   洗浄washed with water
3. 3
   その他dried by nitrogen gas

実験手順

Sulfuric acid (2 mL) in a flask was cooled to 0° C. After ethyl 4-chloroacetoacetate (0.62 g, 3.8 mmol) was added thereto, 2,4-difluororesorcinol (0.5 g, 3.4 mmol) was added dropwise thereto. The mixture was stirred at room temperature for 2 hours, and the reactant was placed in ice water. The precipitate was filtered, washed with water, and dried by nitrogen gas to obtain the title compound (0.2 g, 24%).

出典