反応 #91167

反応方程式

2-(3-fluoro-4-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester

BBr3

MeOH

→

title compound

収率 91.3%

2-[3-fluoro-4-hydroxy-phenyl]-cyclopropanecarboxylic acid ethyl ester

収率 91.3%

溶媒

DCM

反応条件

後処理

1. 1
   その他After the termination of the reaction
2. 2
   濃縮concentrated under reduced pressure
3. 3
   その他purified by column chromatography (eluent, EtOAc/Hex=1/2)

実験手順

After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester (0.494 g, 2.07 mmol) obtained in Step B was dissolved in anhydrous DCM (7 mL), BBr3 1 M DCM solution (3 mL, 3.11 mmol) was added thereto at −78° C., and the mixture was stirred at room temperature for 3 hours. After the termination of the reaction, the reactant was added with MeOH, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/2) to obtain the title compound (0.424 g, 91%).

出典