反応 #91155

反応方程式

2-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropane-carboxylic acid ethyl ester

2-(4-benzyloxy-3,5-difluoro-phenyl)-cyclopropane-carboxylic acid ethyl ester

→

title compound

収率 97.0%

2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropane-carboxylic acid ethyl ester

収率 97.0%

溶媒

EtOH

反応条件

後処理

1. 1
   ろ過The reactant was filtered
2. 2
   濃縮concentrated under reduced pressure

実験手順

2-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropane-carboxylic acid ethyl ester (0.65 g, 1.96 mmol) obtained in Step A was dissolved in EtOH (15 mL), and 10% Pd/C (65 mg) was added thereto. The mixture was stirred at room temperature under hydrogen atmosphere for 3 hours. The reactant was filtered by using celite and concentrated under reduced pressure to obtain the title compound (0.46 g, 97%).

出典