反応 #91113

反応方程式

4-Benzyloxy-3,5-difluoro-benzaldehyde

4-benzyloxy-3,5-difluoro-benzaldehyde

carbethoxymethylene triphenylphosphorane

→

title compound

収率 78.1%

(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester

収率 78.1%

溶媒

THF

反応条件

後処理

1. 1
   その他After the termination of the reaction
2. 2
   温度the reactant was cooled
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他The residue was purified by column chromatography (eluent, EtOAc/Hex=1/10)

実験手順

4-Benzyloxy-3,5-difluoro-benzaldehyde (1.2 g, 4.83 mmol) obtained in Step B and carbethoxymethylene triphenylphosphorane (2.0 g, 5.78 mmol) was dissolved in THF (10 mL), and the solution was stirred at 65˜75° C. for 1 hour. After the termination of the reaction, the reactant was cooled and concentrated under reduced pressure. The residue was purified by column chromatography (eluent, EtOAc/Hex=1/10) to obtain the title compound (1.2 g, 78%).

出典