反応 #90995

反応方程式

methyl 4-(3,5-dichloro-4-hydroxybenzamido)benzoate

Methyl 4-(3,5-dichloro-4-hydroxybenzamido)benzoate

(bromomethyl)cyclopropane

→

Methyl 4-(3,5-dichloro-4-(cyclopropylmethoxy)benzamido)benzoate

収率 103.5%

反応条件

実験手順

Methyl 4-(3,5-dichloro-4-(cyclopropylmethoxy)benzamido)benzoate (6) (120 mg, 100%) was prepared from methyl 4-(3,5-dichloro-4-hydroxybenzamido)benzoate (5) (100 mg, 294 μmol) and (bromomethyl)cyclopropane (57 μL, 588 μmol) using a procedure essentially the same as in Step (i) for AAA-001 except the mixture was stirred at 50° C. for 18 h: m/z 392 (M−H)− (ES−). 1H NMR (400 MHz, DMSO-d6) δ: 7.99 (4H, d), 7.85 (2H, d), 3.99 (2H, d), 3.90 (3H, s), 1.49-1.29 (1H, m), 0.65-0.60 (2H, m), 0.37-0.34 (2H, m).

出典