反応 #909

反応方程式

N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide

Methyl chloroformate

HCl

n-butyllithium

→

title compound

Methyl 3-[[(1,1-dimethylethyl)amino]sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate

溶媒

THF

—

hexanes

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise at such a rate as
2. 2
   その他the temperature below -65° C
3. 3
   温度to warm to room temperature
4. 4
   workup.STIRRINGstirred for ca. 1.5 hours
5. 5
   温度was cooled to 0° C.
6. 6
   その他The THF phase was separated
7. 7
   洗浄washed with brine
8. 8
   乾燥dried (MgSO4)
9. 9
   濃縮concentrated to an ember oil
10. 10
    その他The NMR of the crude reaction product

実験手順

To a solution of I g (4.62 mol) of N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide in 150 mL THF under a nitrogen atmosphere cooled to -78° C. was added dropwise at such a rate as to keep the temperature below -65° C. 4.1 mL (9.48 mmol) 2.32M n-butyllithium in hexanes. The resulting amber turbid solution was stirred at -78° C. for ca. 30 minutes. Methyl chloroformate (0.37 mL, 4.86 mmol) was added in one portion and the resulting gold reaction mixture was allowed to warm to room temperature and stirred for ca. 1.5 hours. The gold reaction mixture was cooled to 0° C. and acidified with 1N HCl. The THF phase was separated washed with brine, dried (MgSO4) and concentrated to an ember oil. The NMR of the crude reaction product was consistent with the title compound, additionally the NMR indicated that a trace of the starting material was also present. The crude material was combined with the product from a similar reaction run on the scale described below and chromatographed to give the title compound.

出典