反応 #90846

ord-e4d92eb81e1047428d952ffc9a9ab295

反応方程式

O=C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O
glucaric acid
O=C(O)[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(=O)O
galactaric acid
→
O=C(O)CCCCC(=O)O
adipic acid

反応物

O=C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O
glucaric acid
O=C(O)[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(=O)O
galactaric acid

試薬

[Re]
rhenium

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.ADDITIONare added to the reaction solvent
  2. 2
    その他reacted together at a proper temperature for a proper reaction time
  3. 3
    その他separated
  4. 4
    その他purified with a conventional method (e.g., purification with silica column)

実験手順

Further, as described above, the starting material (glucaric acid or galactaric acid), rhenium catalyst, and acid catalyst are added to the reaction solvent, and reacted together at a proper temperature for a proper reaction time, then separated and purified with a conventional method (e.g., purification with silica column) to obtain glucaric acid ester or galactaric acid ester as an intermediate of adipic acid. In one embodiment, the reaction temperature ranges from 100 to 200° C., and the reaction time is 12 to 24 hours.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09447012B2uspto-grants-2016_09