反応 #9064

反応方程式

4-(Benzimidazol-2-yl)-benzyl alcohol

→

4-(benzimidazol-2-yl)-benzaldehyde

収率 42.0%

溶媒

CH2Cl2

THF

反応条件

後処理

1. 1
   ろ過The mixture was filtered through celite
2. 2
   洗浄the cake washed with CH2Cl2
3. 3
   その他the solvent from the eluent removed under reduced pressure

実験手順

4-(Benzimidazol-2-yl)-benzyl alcohol from above (0.175 g, 0.78 mmol) was dissolved in CH2Cl2 (5 mL) and THF (8 mL), treated with activated MnO2 (0.68 g, 7.8 mmol) and stirred at room temperature for 1.5 h. The mixture was filtered through celite, the cake washed with CH2Cl2 and the solvent from the eluent removed under reduced pressure to afford 4-(benzimidazol-2-yl)-benzaldehyde (92 mg, 42%). 1H NMR (CD4OD) δ 7.28 (m, 2H), 7.60 (br, 1H (NH)), 7.65 (d, 2H, J=7.8 Hz), 8.09 (d, 2H, J=7.8 Hz), 8.30 (d, 2H, J=9.0 Hz), 10.08 (s, 1H (CHO)).

出典