反応 #90393

反応方程式

VII

(E)-N′-(2,7-dicyanobenzo[d]thiazol-6-yl)-N,N-dimethylformimidamide

4-aminophenol

KBr

→

9-(4-Hydroxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

収率 80.0%

溶媒

EtOAc

反応条件

実験手順

Prepared from VII and 4-aminophenol. Flash chromatography eluent (EtOAc). Yield: 80%; orange solid; mp 236° C.; IR (KBr) νmax/cm−1 3072, 2225, 1641, 1615, 1577, 1503, 1464, 1378, 1350, 1307, 1230, 1212, 1159, 1097, 972, 832; 1H NMR (300 MHz, DMSO-d6) δ 8.48 (d, 1H, J=8.7 Hz), 8.08 (m, 1H), 7.76 (d, 1H, J=8.7 Hz), 7.15 (m, 2H), 6.79 (m, 2H); HRMS calcd for C16H10N5OS (M+H+): 320.0606, found 320.0619.

出典